CBTN 2024 SUMMIT AGENDA

8:00-8:30 a.m.

Morning Kickstart: Breakfast and Networking Session

8:30-8:45 a.m.

Welcome
Presented by Brian Rood (Children’s National) and Javad Nazarian (Children’s National)
Introducing Patient Advocate Nicole Giroux of the Lilabean Foundation

Session 1: New Frontiers: Pediatric Brain Tumors and NIH Kids First Data Resource
8:45 a.m.-Noon
Moderated by Adam Resnick (CBTN/Children’s Hospital of Philadelphia)

8:45-9:15 a.m.
Keynote: Invested in Pediatric Health in the Era of AI
Sponsored by Lilabean Foundation
Presented by Dr. Rowland Illing, Chief Medical Officer & Director, Global Healthcare and Non-Profits
(Amazon Web Services)

9:20-9:40 a.m.
The Future of Pediatric Research: Introducing Kids First 2.0
Presented by James Coulombe (formerly of the NIH)

9:40-10 a.m.
CBTN and Kids First: Integrating Data and Portals
Presented by Vincent Ferretti (St. Justine), Adam Resnick (CBTN/CHOP)

10-10:20 a.m.
Break

10:20-10:40 a.m.
Emerging Opportunities: Pediatric Cancer and Congenital Birth Defects Research
Presented by Jeremy Schraw (Texas Children’s)

10:40-11 a.m.
Pioneering Precision: Preclinical Models and Drug Screening
Presented by Ron Firestein (Hudson Institute of Medical Research)

11-11:20 a.m.
Advancing Detection: Liquid Biopsy in Kids First Research
Presented by Ching Lau (The Jackson Laboratory)

11:20-11:40 a.m.
Single-cell studies of pediatric brain tumors identify novel therapeutic targets
Presented by Aaron Diaz (UCSF)

11:40 a.m.-noon
Leveraging Post-Mortem Brain Tissue for Breakthroughs
Presented by Javad Nazarian (Children’s National)

12:00-12:10 p.m.
Beyond boundaries: New models of collaboration to conquer pediatric brain tumors
Presented by Stephanie MacMahon (Connor’s Cure)

12:10-1:30 p.m.

Lunch
Training Track: Move to Skills Center for Kids First Portal Training session
Concurrent: Gift From A Child Working Lunch

Session 2: Bridging Breakthroughs: Pediatric Brain Tumors & NCI Childhood Cancer Data Initiative
Moderated by Carl Koschmann (University of Michigan Medicine)
1:30-3:25 p.m.

1:30-1:50 p.m.
Childhood Cancer Data Initiative (CCDI) and CBTN Collaboration
Presented by Warren Kibbe (National Cancer Institute)

1:50-2:10 p.m.
CCDI Molecular Characterization Initiative
Presented by Sarah Leary (Seattle Children’s)

2:10-2:30 p.m.
CCDI Federated Imaging Analysis
Presented by Ariana Familiar (Children’s Hospital of Philadelphia) and Shannon Silkensen (National Cancer Institute)

2:30-2:50 p.m.
Break

2:50-3:35 p.m.
Panel Session: Transforming Pediatric Brain Tumor Care: From Diagnostics to Prevention through Network Collaboration
Panelists: James Coulombe (Formerly NIH), Sara Leary (Seattle Children’s), Suzanne MacFarland (Children’s Hospital of Philadelphia), Nora Sobreira (Johns Hopkins) 

Session 3: Empowering Pediatric Brain Tumor Research: Enhancing Multimodal Data Accessibility and Usability with Emerging AI and ML Technologies
Moderated by Javad Nazarian (Children’s National)
3:45-5:15 p.m.

3:45-4:05 p.m.
Introduction to Generative AI Use Case
Presented by Rod Tarrago (AWS)

4:05-4:25 p.m.
DAVIDai Prelude
Presented by Allison Heath (CBTN/CHOP)

4:25-4:55 p.m.
Levering emerging technologies Kno2/Mulesoft
Presented by Sam Sloan (MuleSoft) and Travis White (Kno2)

4:55-5:30 p.m.
Lightning Talks with Andrea Di Micheli (Zurich), Yiming Deng (JHU) and Elton VanNoy (CNMC)

Session 4: Exploring New Frontiers: Scientific Poster and Education Session on Advances in Pediatric Brain Tumor Research and Technologies
5:30-9:00 p.m.

5:30-7 p.m.
Poster Sessions & Demonstrations
Sponsored by Mulesoft/Kno2

7-9 p.m.
Cocktail Hour & Networking
Sponsored by AstraZeneca

8:00-8:30 a.m.

Morning Kickstart: Breakfast and Networking Session

8:30-8:45 a.m.

Welcome
Presented by Carl Koschmann (University of Michigan Medicine)
Introducing Patient Advocate Robert Martin of the Bridge To A Cure Foundation

Session 1: Transforming Pediatric Brain Tumor Care: Actionable Insights from Hospital EHRs
8:45-11:00 a.m.

8:45-9:15 a.m.
Keynote: ASTP/ONC’s Journey: Then and Now
Presented by Melinda Kidder, Chief Nursing Officer at the Office of the National Coordinator for Health IT (ONC)

9:15-9:35 a.m.
Enhancing Real world workflows for imaging analytics and clinical trials
Presented by Ariana Familiar (CBTN/CHOP)

9:35-9:55 a.m.
ARPA-H, CBTN, PNOC, ATRT Registry Pilot Update
Presented by Ashley Margol, (Children’s Hospital LA) and Adam Resnick (CBTN/CHOP)

9:55-10:15 a.m.
Break

10:15-10:35 a.m.
Leveraging CBTN data to inform translational studies in atypical teratoid rhabdoid tumor
Presented by Eric Raabe (Johns Hopkins)

10:35-11 a.m.
ExtractEHR
Presented by Tamara Miller (Children’s Hospital of Atlanta)

Session 2: Navigating New Horizons: Pediatric Brain Tumors, Cloud and AI Considerations
Moderated by Jay Storm (CBTN/Children’s Hospital of Philadelphia)
11 a.m.-Noon

11 a.m.-Noon
Panel Discussion: Navigating New Horizons: Pediatric Brain Tumors, Cloud and AI Considerations that Clinical Enterprises Must Make
Panelists: Shakeeb Akhter (Children’s Hospital of Philadelphia), Allison Health (CBTN/Children’s Hospital of Philadelphia), Travis White (Kno2)
Moderator: Rod Tarrago (AWS)

12:00-1:10 p.m.

Lunch
Training Track: Move to Skills Center for PedcBioPortal Training session

Session 3: CBTN at the Forefront: Leading the Multiomic, Multimodal Data Revolution
Moderated by Adam Resnick (CBTN/Children’s Hospital of Philadelphia)
1:10-4:40 p.m.

1:10-1:50 p.m.
Keynote: Cloud and AI in the Clinical Enterprise
Presented by Shakeeb Akhter (Children’s Hospital of Philadelphia)

1:50-2:10 p.m.
Advancing Intraoperative Brain Tumor Diagnostics with AI
Presented by Todd Hollon (University of Michigan Medicine)

2:10-2:20 p.m.
CPTAC Overview
Presented by Henry Rodriguez (National Cancer Institute)

2:20-2:35 p.m.
Break

2:35-2:55 p.m.
CPTAC Project Hope: High-Grade Gliomas Across the Ages
Presented by Nicole Tignor (Mount Sinai)

2:55-3:15 p.m.
Exploring New Dimensions: Multimodal Clustering in Kids First Data Modalities and Assays
Presented by Adam Kraya (Children’s Hospital of Philadelphia) and Brian Rood (Children’s National)

3:15-3:35 p.m.
Pediatric Brain Tumor-oids to Optimize Precision Medicine
Presented by Carl Koschmann (University of Michigan Medicine)

3:35-4:30 p.m.
Keynote: Immune Therapies: Implementing AI, data, and Controlled Manufacturing to Improve cost, Quality, and Predictive outcomes
Presented by Ken Harris (OmniaBio)

4:30-4:45 p.m.
Fueling the flame: Inspiring Research Breakthroughs in the Coming Year
Presented by Amanda Haddock (Dragon Master Initiative)

Closing Remarks
Moderated by Brian Rood (Children’s National), Carl Koschmann (University of Michigan Medicine) and Javad Nazarian (Children’s National)
4:45-5:00 p.m.

9:00-11:00 a.m.
CBTN Clinical Data Research Session

Interest Group and Feedback Forum

10:00 a.m.-Noon

CBTN Advanced Analytics Workshop: Deploying AWS Gen AI Tooling for the Clinical Dataset 

By the end of this session, attendees will be able to:

• List 3 uses where Generative AI can be useful in Clinical Research
• Define Retrieval Augmented Generation (R.A.G.)
• Describe the steps in data flow and process flow for making GenAI possible.

There will be an in-person scientific talk on this topic Day 2 from 9:15-9:30 a.m. for those registered for the CBTN Summit

Tools and Services: Bedrock, SageMaker
Instructor: Curtis Evans (AWS), Meen Kim (D3b) and Qing Liu (AWS)

Noon-1:00 p.m.

CBTN Hands On! “Create Your Research Cohort” (option 1)

By the end of this session, attendees will be able to:

• Create an account on the Kids First Portal & PedcBioPortal
• Create a project cohort based on clinical and biospecimen criteria
• Identify biosamples and understand what data is available for those samples
• Share a project cohort to request resources

Tools and Services: Kids First Portal, PedcBioPortal, S3
Instructor: David Higgins (D3b)
Target Audience: All, clinical researchers, bioinformatics, and biomedical researchers
Location: Skill Center, Classroom 2

1:00-2:00 p.m.

CBTN Hands On! “Create Your Research Cohort” (option 2)
By the end of this session, attendees will be able to:

• Create an account on the Kids First Portal & PedcBioPortal
• Create a project cohort based on clinical and biospecimen criteria
• Identify biosamples and understand what data is available for those samples
• Share a project cohort to request resources

Tools and Services: Kids First Portal, PedcBioPortal, S3
Instructor: David Higgins (D3b)
Target Audience: All, clinical researchers, bioinformatics, biomedical researchers
Location: Skill Center, Classroom 2

2:00-4:00 p.m.

CBTN Advanced Analytics Workshop: Leveraging LLM-Based Chatbots to Enhance Pediatric Genomic Research
By the end of this session, attendees will be able to:

• Automate near-real time extraction of FHIR-structured data from the EHR using Mulesoft/AWS Helathlake
• Integrate EHR data from multiple health systems via KNO2/Mulesoft
• No-code development of predictive analytics and models (Sagemaker) (hands on from AWS)

There will be an in-person scientific talk on this topic Day 2 from 10:00-10:15 a.m. for those registered for the Annual Scientific Summit

Tools and Services: Bedrock, Athena
Instructor: Curtis Evans (AWS), Meen Kim (D3b) and Qing Liu (AWS)
Location: Skill Center, Classroom 1

5:30-7:00 p.m.

CBTN Research Resource and Platform Fundamentals Training Demos
By the end of this session, attendees will be able to:

• Create your cohort on the Kids First Portal
• Create your own cohort on the PedcBioPortal
• How to request access to CBTN data or specimens

Tools and Services: Kids First Portal, PedcBioPortal, S3
Instructor: David Higgins
Location: Poster Session (Network Event Room)

10:00 a.m.-Noon

CBTN Advanced Analytics Workshop: Multi-modal Imaging Analysis
By the end of this session, attendees will be able to: 

• Access and use CBTN radiology and pathology imaging cohorts in Flywheel
• Volumetrics and feature extraction and integration of radiology and histology files in Flywheel
• Create imaging-based diagnostic classifiers in the cloud

There will be an in-person scientific talk on this topic Day 2 from 9:45-10:00 a.m. for those registered for the Annual Scientific Summit

Tools and Services: Flywheel
Instructor: Ariana Familiar, PhD (D3b)
Location: Skill Center, Classroom 1

Noon-1:00 p.m.

CBTN Hands On! Create Your Research Cohort
By the end of this session, attendees will be able to:

• Create an account on the Kids First Portal & PedcBioPortal
• Create a project cohort based on clinical and biospecimen criteria
• Identify biosamples and understand what data is available for those samples
• Share a project cohort to request resources

Tools and Services: Kids First Portal, PedcBioPortal, S3
Instructor: David Higgins (D3b)
Target Audience: All, clinical researchers, bioinformatics, biomedical researchers
Location: Skill Center, Classroom 2

1:00-2:00 p.m.

PedcBioPortal 102: Advanced Cohort Building and Comparisons
By the end of this session, attendees will be able to:

• Create an account on PedcBioPortal
• Identify subjects of interest by molecular classification (somatic mutations or gene expression)
• Perform a cohort comparison by molecular classification and clinical outcome data

Tools and Services: PedcBioPortal, S3
Instructor: David Higgins (D3b)
Target Audience: All, clinical researchers, bioinformatics, biomedical researchers
Location: Skill Center, Classroom 1

2:00-4:30 p.m.

CBTN Advanced Analytics Workshop: Bioinformatic Analysis of Multi-omic Data
By the end of this session, attendees will be able to:

• Access multi omic PBTA data in a private project in CAVATICA.
• Integrate data and tumor classification in CAVATICA (Jupyter Notebooks/Rstudio environments)
• Run workflows in CAVATICA  (WGS, RNAseq, etc.)

There will be an in-person scientific talk on this topic Day 2 from 10:00-10:15 a.m. for those registered for the Annual Scientific Summit

Tools and Services: Cavatica, S3
Instructors: Yuankun Zhu, Adam Kraya (D3b)
Location: Skill Center, Classroom 1

9:00-10:00 a.m.

CBTN Hands On! “Create Your Research Cohort”
By the end of this session, attendees will be able to:

• Create an account on the Kids First Portal & PedcBioPortal
• Create a project cohort based on clinical and biospecimen criteria
• Identify biosamples and understand what data is available for those samples
• Share a project cohort to request resources

Tools and Services: Kids First Portal, PedcBioPortal, S3
Instructor: David Higgins
Location: Skill Center, Classroom 1